Dengue virus exhibits a very strange phenomenon known as
antibody-dependent enhancement (ADE) where the antibodies against one strain of
the virus can worsen the effects of being infected by another strain. This is
known and expected, and scientists are in the process of figuring out how to
reduce this.
However, a concern has risen that dengue might not be the
only virus exhibiting this phenomenon. Zika might be joining the party.
Due to the pregnancy-specific effects of Zika, such as
microcephaly and other severe birth defects, scientists are beginning to
investigate whether Zika cross-reacts with dengue and whether prior dengue infection
could worsen the effects of Zika. Considering that both dengue and Zika are very
similar viruses: they’re both flaviviruses transmitted by mosquitos and ticks, it
wouldn’t be surprising to see the ADE phenomenon occur between these two.
Lab experiments are currently in progress for determining
whether this is true. Some previous assessments of South American populations
have suggested that it may be false, and that dengue may actually offer a
protective effect. Hopefully, scientists can discover whether there is any
phenomenon occurring between Zika and dengue so that the correct public health measures
can be put in place to keep populations as healthy as possible. But for now,
don’t forget your bug spray.
-Mailo Numazu
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