Based on a recent study of the 17-18 flu vaccine, concerns are arising over how effective egg-based vaccines are. This past year’s vaccine was disappointingly ineffective, with a 40% effectiveness according to the CDC. Researchers at the University of Michigan teamed up with the CDC to take a look at effectiveness of egg-grown versus cell-grown viruses.
The investigators took serum samples 15 cases with recently diagnosed influenza A (H3N2) and took samples in 15 hospitalized controls without influenza. The team measured titers against egg and cell-grown strains, and a set of circulating viruses for comparison. They found that those vaccinate in 17-18 had high antibody titers against the egg strain and lower against circulating viruses. They concluded that titers against circulating viruses were protective but those against egg-adapted strains weren’t.
Studies have shown that egg-based vaccines tend to mutate with time. Ian Wilson, DPhil, a professor of structural biology at the Scripps Research Institute, in California proposes an explanation citing that influenza viruses made in eggs have the opportunity to adapt in this environment and can generate mutations to grow better as a result.
Read more at: https://www.mdmag.com/medical-news/eggbased-vaccines-less-protective-against-circulating-flu-viruses
-Brittany Stinson
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