The 2015 epidemic of Zika virus in Brazil and the Americas launched a global search for a vaccine, and researchers at Yale University are investigating Aedes aegypti (the mosquito that carries and transmits Zika) to find new strategies for vaccines against mosquito-borne illnesses.
The team took the blood of mice that had been bitten by mosquitoes and isolated antibodies, identified mosquito proteins using a genomic screen, and examined the effects of these mosquito proteins on Zika infection in vitro and in vivo. One of those proteins, AgBR1, exacerbated Zika infection in mouse models. They then tested AgBR1 inhibition in vivo using an antiserum, which reduced Zika viral loads over time and provided partial protection against advanced disease and death.
Led by Prof. Erol Fikrig, Section Chief of Infectious Diseases at the Yale School of Medicine, the team published their work in Nature Microbiology. This work points to mosquito salivary proteins as potential targets when engineering vaccines against mosquito-borne flaviviruses like Zika.
Read more at: https://www.sciencedaily.com/releases/2019/03/190311125346.htm
- Arjun Kumar
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