New research from Johns Hopkins Medicine and Sheppard Pratt Health System shows an association between schizophrenia and a heightened immune response to Epstein-Barr Virus, a viral species in the family Herpesviridae that causes mononucleosis. EBV causes flu-like symptoms, extreme fatigue, and swollen lymph nodes; its typically transmitted through oral contact such as kissing. Rarely, EBV can spread to the central nervous system and cause severe, persistent infection. In a study among 743 participants -- 432 with a schizophrenia diagnosis and 311 without a history of a psychiatric disorder, scientists measured the antibodies for EBV, and related viruses including varicella, and herpes simplex-1. However, only EBV antibody levels differed between the two groups, suggesting that only EBV is associated with increased risk of schizophrenia. Researchers have two potential hypotheses for the cause of this correlation-- either, exposure to Epstein-Barr virus increases the risk of developing schizophrenia by impacting the nervous system in some way, or schizophrenia modifies the immune system in some way that makes individuals more susceptible to EBV. More research will be necessary to explore the mechanism behind this correlation, however, the topic doesn't lend itself to randomized control trial, arguably the most foolproof way to test hypotheses, because of the ethical ramifications involved. Future research may take the form of a prospective longitudinal study. Only time can tell whether this correlation proves to be causational.
Reference: https://www.hopkinsmedicine.org/news/newsroom/news-releases/schizophrenia-linked-with-abnormal-immune-response-to-epstein-barr-virus
~Lisa Manzanete
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