In 2015, a massive Zika outbreak hit South America. Originally thought to be a typical Flavivirus, Zika soon proved to be a greater health risk than anticipated, as it was found that Zika infection during pregnancy drastically increased the occurrence of a rare neurodevelopmental disorder known as microcephaly. Though many public health measures have been taken to protect against the emergent virus, including the ongoing development of a vaccine, the virus continues to spread, recently appearing in an ongoing outbreak in India that started in 2018.
The results of a recent study, however, may complicate these efforts. The report, published February 8th in the journal Immunity, has provided evidence that prior Dengue infection may be linked with more severe outcomes from Zika infection. Zika and Dengue are closely related, and this effect, where prior exposure to one predisposes an individual to worse outcomes from the other, is known to occur between various strains of Dengue. The study, conducted in pregnant mice, was far from conclusive, but it could possibly indicate that a potential Zika vaccine, like recent Dengue preventative “Dengvaxia,” could cause this effect, and lead to more harm than good.
This early warning is not as clear as it may seem. A report from the NIH just 2 weeks ago found a seemingly opposite effect; that prior Dengue infection can lead to immunity to Zika infection. Only time, and future experimentation, will reveal the true safety of a potential Zika preventative.
-J Cole Holderman (Dengue Aficionado)
Report: https://www.sciencedaily.com/releases/2019/02/190208131409.htm
Paper 1:https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002726
Paper 2:https://linkinghub.elsevier.com/retrieve/pii/S1074761319300287
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