Friday, January 11, 2019
Schizophrenia and the Epstein-Barr Virus
The Epstein-Barr virus is the most common cause of mononucleosis, or the kissing disease. The study conducted at Johns Hopkins University did not seek to determine cause and effect but it noted an association.
The study found that subjects with schizophrenia had markedly higher levels of antibody related to EBV virions versus the control. They conducted a genetic analysis, which indicated an additive effect of increased levels EBV virion antibodies and genetic susceptibility to schizophrenia. Those with both marker combined had greater than 8.5x odds of receiving a schizophrenia diagnosis relative to the control. Those with schizophrenia had higher levels of only some EBV protein antibodies but not all, still indicating an abnormal response to EBV infection.
In conclusion,
Schizophrenia might alter immune systems and make patients more susceptible to the Epstein-Barr virus, or EBV infection might increase the risk of schizophrenia.
-Brittany Stinson
Sources:
https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sby164/5193713
https://www.futurity.org/schizophrenia-epstein-barr-mononucleosis-virus1952692-2/
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