Molecular oncologist Fumihiro Higashino and other researchers at Hokkaido University have engineered dl355, a new oncolytic virus which appears to have greater efficacy than the dl1520 oncolytic virus currently used in clinical practice. The virus was engineered from an adenovirus, which was made replication-incompetent by deletion of the E4orf6 gene for ARE-mRNA stabilization. ARE-mRNAs are known to be stable in cancer cells but rapidly degrade in healthy cells without the presence of E4orf6; by deleting E4orf6, the researchers generated a virus that could replicate only in cancer cell environments where ARE-mRNAs were naturally stable.
In work published in Oncology Reports, a dose of 100 viral particles per cell killed nearly all cancer cells within a week (as opposed to very few healthy cells), and the few cancer cell lines that survived were also killed by increasing the dosage. Testing in preclinical mouse models showed that growth of human tumors was suppressed via dl355 administration, and dl355 outperformed the dl1520 oncolytic virus currently used in the clinic. Future studies will focus on validating/building on the safety data and improving the efficacy by enhancing ARE-mRNA stabilization in cancer cells.
Read more at: https://www.sciencedaily.com/releases/2019/01/190129093709.htm
- Arjun Kumar
Hello everyone, I was infected with the Epstein-Barr virus and I got cured from the Epstein-Barr virus few months ago after i contacted Chief Dr Wealthy. I saw a post on the internet after i have seek healing for several years from different doctors in California. I sent the Doctor a request for help, just a few email i followed his instruction and he sent me the medication. Now i am negative and i referred him to all my friend who had this same sickness and they have gotten their cure too. You can contact him via his email: wealthylovespell@gmail.com or Phone call or whatsAPP: +2348105150446. While i was on his medication i understood that he can also cure HERPES, HIV/AIDS, CANCER, Male/female menopause, Miscarriage, Menstruation problems, PREGNANCY PROBLEM, EPILEPSY, GONORRHEA, LASSA FEVER, OBESITY, KIDNEY FAILURE, HYPERTENSION, FIBROID TUMOR, BRAIN FOG, EPSTEIN-BARR VIRUS and many more.
ReplyDeleteContact him today and get your problem solved.