Virology
in 2016 and 2017 saw a great deal of attention paid towards Zika Virus (ZIKV)
outbreaks in the Americas. In addition, recent introduction of West Nile virus
to the Americas as of 1999 sees the field of virology and infectious disease
adapting to the potential for these infections in a wide variety of patient
populations. Work very recently published by Robinson, Enriquez, and Ho
synthesized a body of work surrounding the development of WNV and ZIKV in the
Americas, specifically as infection and standards of treatment apply to Solid
Organ Transplantation (SOT) patient populations. Given the knowledge that WNV
and ZIKV are both flaviviruses, the analysis of incidence and epidemiology
involved in flavivirus infection in SOT patients is essential to the
development of therapeutic techniques for these types of infections. This
review is novel in that it holistically reviews cases of flavivirus infection
in SOT, where donor-derived disease and increased disease severity are
continuing to be fully understood in immunocompromised patient populations. In
analyzing these two sources of disease within the same context as a viral
family, insight was gained as to the progress that has been made in the field
regarding SOT infectious disease as a whole and suggests potential next steps
for development of diagnostics and treatments for flaviviruses. As clinical and
scientific understanding of this virus develops, it is essential for practicing
physicians to continue to develop protocols to protect SOT and
immunocompromised patients, in addition to driving research into the
afflictions that do not have optimal treatments. Work continues to try and
develop vaccines and treatments for the diseases caused by these flaviviruses, and
has resulted in many new types of Immunoglobulin based assays for the detection
of viral titers in patients. This work is especially important for the
immunocompromised patient and SOT communities, as limited data suggests that
both WNV and ZIKV infections become exaggerated and more dangerous for these
populations. Future work also continues to focus on the treatment of mosquito
vectors to prevent their spread of the disease, with researchers finding new
ways to either combat the disease within the mosquito or to combat the mosquito
itself, much like the work of those combatting Yellow Fever in the late 1800's.
Source: Robinson
ML, Enriquez K, Ho DY. A Tale of Two Flaviviruses: West Nile Virus and Zika
Virus in Solid Organ Transplantation. OBM Transplantation 2019;3(1):32;
doi:10.21926/obm.transplant.1901038.
~Kyle Enriquez
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