Investigators at the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases have developed an investigational treatment for Ebola, and results from a Phase 1 clinical trial were recently published in The Lancet. The study generated promising safety data, with the treatment appearing both well-tolerated and easy to administer to the 18 healthy adults who participated in the trial.
An often-fatal disease caused by a group of five species in the Ebolavirus genus (part of the Filovirus family), Ebola has had a severe human and societal impact in recent years - including a major epidemic in West Africa in 2014. The NIH investigators sought to address it with mAb114, a single monoclonal antibody aimed at the Zaire ebolavirus strain. The antibody binds to the core receptor binding domain on the virus's envelope protein, preventing it from entering human cells. All infusions of the antibody were well-tolerated, and four of the eighteen participants reported mild side effects. Absorption, distribution, and elimination of the antibody were all uniform among participants, paving the way for further trials.
Importantly, mAb114 does not require a cold chain and can be easily stored and administered, making it very useful for outbreak settings in the field. The treatment is already being offered under compassionate use to Ebola patients in the Democratic Republic of the Congo, as well as as part of a combination therapy in a Phase 2/3 clinical trial.
Read more at: https://www.sciencedaily.com/releases/2019/01/190124193403.htm
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