HIV has been playing a game of hide-and-seek for years with scientists
in search of a cure. We first found it’s sequelae, a rare lung infection and an
aggressive cancer. We then discovered that these conditions were caused by a
weakened immune system, later to be termed AIDS, and even later to be
discovered as HIV’s later form. The actual retrovirus that causes AIDS wasn’t
discovered for a few more years. And this might’ve been the end of the road and
we probably could’ve found a cure in the antiretroviral treatments we created.
Except HIV sits latently in the body for decades until activating later in life
causing AIDS, which the antiretroviral drugs have no effect on.
This latent reservoir of HIV is a roadblock to scientists’
discovery of a cure. Part of this roadblock is our inability to tell how big
this reservoir is in each patient making every trial of experimental therapies
a shot into the void.
However, a team at the Howard Hughes Medical Institute may
have shed some light on this part of HIV, effectively ending it’s game of
hide-and-seek. Their method of detecting the latent reservoir involved
distinguishing between unaffected and productively infected cells, which allows
for more precise quantification of the hidden virus.
While this isn’t a solid method yet that has revealed all
about HIV, it is a big step forward towards curing HIV. By knowing how much
virus is initially in the patient before the treatment and how much is present
after will be key in telling whether things are working and decreasing the
disease. HIV is a global disease affecting millions of people and leading to
the death of millions of others. If a cure can be found, quality of life around
the world will be improved greatly. With this new quantitative technique, maybe
we will see this cure in our lifetime.
-Mailo Numazu
Source:
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